He ʻano maʻamau ka Rosacea i hōʻike ʻia e ka ʻulaʻula o ka maka a me ka pehu ʻana. Hoʻopilikia ia ma kahi o 5% o ka heluna kanaka o ka honua, a ʻoiai ua ʻike ʻia nā kumu, ʻaʻole i ʻike nui ʻia. Ua manaʻo ʻia he ʻano ʻili lōʻihi ia, a ʻo ka hapa nui e hoʻopilikia i nā wahine ʻEulopa/Caucasian ma luna o 30 mau makahiki. Aia nā ʻano ʻano like ʻole o ka rosacea a hiki ke hoʻopilikia i kekahi.
Ua aʻo maikaʻi ʻia ka lāʻau lapaʻau kukui ʻulaʻula no nā mea e like me ka ho'ōla ʻana i ka ʻili, ka mumū ma ke ʻano laulā, ka collagen i loko o ka ʻili, a me nā ʻano ʻili like ʻole e like me ka ʻākena.ʻOiaʻiʻo, ua ulu ka hoihoi i ka hoʻohana ʻana i ke kukui ʻulaʻula no ka rosacea. Ma kēia ʻatikala e nānā mākou inā paha e hiki i ka lāʻau lapaʻau kukui ʻulaʻula (ʻike ʻia hoʻi ʻo photobiomodulation, LED therapy, laser therapy, cold laser, light therapy, LLLT, etc.) ke kōkua i ka mālama ʻana i ka rosacea.
Nā ʻano o Rosacea
He ʻokoʻa iki a kū hoʻokahi ko kēlā me kēia kanaka i loaʻa i ka rosacea. ʻOiai ʻo ka rosacea e pili pinepine ʻia me ka ʻulaʻula o ka maka a puni ka ihu a me nā papālina, aia kekahi mau hōʻailona ʻē aʻe i hiki ke hoʻokaʻawale ʻia a hoʻokaʻawale ʻia i loko o nā 'subtypes' rosacea:
ʻO ke ʻano liʻiliʻi 1, i kapa ʻia ʻo 'Erythematotelangiectatic Rosacea' (ETR), ʻo ia ka rosacea maʻamau e hōʻike ʻia me ka ʻulaʻula o ka maka, ka mumū o ka ʻili, nā kīʻaha koko kokoke i ka ʻili a me nā wā o ka flushing. Loaʻa ka Erythema mai ka huaʻōlelo Helene erythros, ʻo ia hoʻi ka ʻulaʻula - a pili i ka ʻili ʻulaʻula.
ʻO ke ʻano 2, ʻo Acne rosacea (inoa ʻepekema - papulopustular), ʻo ia ka rosacea kahi i hui pū ʻia ai ka ʻili ʻulaʻula me nā haki ʻana e like me ka acne mau a i ʻole intermittent (pustules a me papules, ʻaʻole nā ʻeleʻele). Hiki i kēia ʻano ke hana i kahi manaʻo wela a ʻā paha.
ʻO ke ʻano liʻiliʻi 3, ʻo ia hoʻi ʻo phymatous rosacea a i ʻole rhinophyma, he ʻano kakaikahi o ka rosacea a pili i nā ʻāpana o ka maka e mānoanoa a nui aʻe - ʻo ia hoʻi ka ihu (ihu ʻuala). He mea maʻamau ia i nā kāne ʻelemakule a hoʻomaka pinepine ia ma ke ʻano he ʻano ʻē aʻe o ka rosacea.
ʻO ke ʻano 4 ka rosacea o ka maka, a i ʻole ka rosacea ocular, a pili ia i nā maka ʻulaʻula, nā maka waimaka, kahi manaʻo o kahi mea i loko o ka maka, ke kuni, ka maneʻo a me ka ʻōpala.
He mea nui ka ʻike e pili ana i nā ʻano ʻano like ʻole o ka rosacea i ka hoʻoholo ʻana inā loaʻa maoli iā ʻoe. Inā ʻaʻohe mea i hana ʻia e hoʻoponopono ai i ka rosacea, e lilo ia i mea ʻino i ka hala ʻana o ka manawa. ʻO ka mea pōmaikaʻi, ʻaʻole e loli ka hoʻohana ʻana o ka lāʻau lapaʻau kukui ʻulaʻula i ka mālama ʻana i ka rosacea me ke ʻano like. ʻO ia hoʻi, e hana like ke kaʻina hana lāʻau lapaʻau kukui ʻulaʻula no nā ʻano ʻano like ʻole. No ke aha mai? E nānā kākou i nā kumu o ka rosacea.
ʻO ke kumu maoli o Rosacea
(...a no ke aha e hiki ai i ka lāʻau lapaʻau kukui ke kōkua)
I kekahi mau makahiki i hala aku nei, ua manaʻo mua ʻia ʻo ka rosacea ka hopena o kahi maʻi bacteria. ʻOiai ua hana nā antibiotics (me ka tetracycline) i kahi kekelē e hoʻokele i nā hōʻailona, ua like ia me kahi manaʻo maikaʻi .... akā ua ʻike koke ʻia ʻaʻohe bacteria i komo.
ʻO ka hapa nui o nā kauka a me nā loea i ka rosacea i kēia mau lā e haʻi iā ʻoe he mea pohihihi ka rosacea a ʻaʻohe mea i ʻike i ke kumu. E kuhikuhi kekahi i nā mites Demodex ma ke ʻano he kumu, akā kokoke i nā kānaka a pau kēia mau mea a ʻaʻole i loaʻa i nā kānaka a pau ka rosacea.
A laila e papa inoa lākou i nā 'mea hoʻoulu' like ʻole ma kahi o ke kumu, a i ʻole e hāʻawi i nā manaʻo he kumu nā genetics i kuhikuhi ʻole ʻia a me nā mea pili i ke kaiapuni. ʻOiai hiki i nā mea genetic a epigenetic paha ke hoʻoholo i kekahi e loaʻa i ka rosacea (e pili ana i kekahi kanaka ʻē aʻe), ʻaʻole lākou e hoʻoholo - ʻaʻole lākou ke kumu.
He nui nā kumu e kōkua maoli i ka koʻikoʻi o nā hōʻailona rosacea (caffeine, nā mea ʻala, kekahi mau meaʻai, ke anuanu/wela, ke kaumaha, ka waiʻona, a me nā mea ʻē aʻe), akā ʻaʻole lākou ke kumu.
No laila he aha?
Nā hōʻailona i ke kumu
ʻO ka hōʻailona mua i ke kumu, ʻo ia ka ʻoiaʻiʻo e ulu pinepine ana ka rosacea ma hope o 30 mau makahiki. ʻO kēia ka makahiki e ʻike ʻia ai nā hōʻailona mua o ka ʻelemakule. E ʻike ka hapa nui o ka poʻe i ko lākou lauoho hina mua a me nā ʻōniʻoniʻo ʻili liʻiliʻi mua a puni kēia makahiki.
ʻO kekahi hōʻailona ʻē aʻe, ʻo ia ka ʻoiaʻiʻo e kōkua ana nā lāʻau antibiotic i ka hoʻokele ʻana i nā hōʻailona - ʻoiai ʻaʻohe maʻi maoli (hōʻailona: hiki i nā lāʻau antibiotic ke loaʻa nā hopena anti-inflammatory pōkole).
ʻO ke kahe koko i ka ʻili i hoʻopilikia ʻia e ka rosacea he 3 a 4 mau manawa kiʻekiʻe aʻe ma mua o ka ʻili maʻamau. Hana ʻia kēia hopena hyperemia ke hiki ʻole i nā ʻiʻo a me nā cell ke unuhi i ka oxygen mai ke koko.
Ua ʻike mākou ʻaʻole wale ka rosacea he pilikia hoʻonaninani, akā pili pū kekahi i nā loli ulu fibrotic koʻikoʻi i ka ʻili (no laila ka ihu ʻuala ma ke ʻano 3) a me ka ulu ʻana o nā kīʻaha koko invasive (no laila nā veins/flushing). Ke hana ʻia kēia mau hōʻailona like ma kahi ʻē aʻe o ke kino (e like me nā fibroids uterine) pono lākou i ka noiʻi koʻikoʻi, akā i loko o ka ʻili ua hoʻokuʻu ʻia lākou he mau pilikia hoʻonaninani e 'hoʻokele' ʻia e ka 'pale ʻana i nā mea hoʻoulu', a ma hope aku hiki i nā ʻoki ʻana e wehe i ka ʻili mānoanoa.
He pilikia koʻikoʻi ka Rosacea no ka mea ʻo ke kumu kumu nā kaʻina hana physiological i loko o ke kino. ʻO ke kūlana physiological e alakaʻi ana i kēia mau loli ʻili ʻaʻole ia e hoʻopilikia wale i ka ʻili - hoʻopilikia pū ia i ke kino holoʻokoʻa.
Hiki ke ʻike maʻalahi ʻia ka ʻulaʻula, nā kīʻaha koko e ulu ana/komo a me ka mānoanoa o ka ʻili i ka rosacea, no ka mea, ua ʻike ʻia ia ma ka ʻili - ka ʻili o ke kino. Ma kekahi ʻano, he pōmaikaʻi ka loaʻa ʻana o nā hōʻailona rosacea, no ka mea, hōʻike ia iā ʻoe he hewa kekahi mea i loko. ʻO ka nalowale o ka lauoho kāne he mea like ia ma ke kuhikuhi ʻana i ka dysregulation hormonal ma lalo.
Nā hemahema mitochondrial
ʻO nā nānā ʻana a me nā ana āpau e pili ana i ka rosacea e kuhikuhi ana i nā pilikia mitochondrial ma ke ʻano he kumu o ka rosacea.
ʻAʻole hiki i ka Mitochondria ke hoʻohana pono i ka oxygen ke hōʻino ʻia. ʻO ka hiki ʻole ke hoʻohana i ka oxygen e hoʻonui i ke kahe o ke koko i kahi ʻiʻo.
Hoʻopuka ka Mitochondria i ka waikawa lactic ke hiki ʻole iā lākou ke loaʻa a hoʻohana i ka oxygen, kahi e alakaʻi ai i ka vasodilation koke a me ka ulu ʻana o nā fibroblasts. Inā hoʻolōʻihi ʻia kēia pilikia i kekahi manawa, hoʻomaka nā kīʻaha koko hou e ulu.
Hiki i nā ʻano hormonal a me nā mea pili i ke kaiapuni ke kōkua i ka hana mitochondrial maikaʻi ʻole, akā i loko o ka pōʻaiapili o ka lāʻau lapaʻau kukui ʻulaʻula, ʻo ka hopena koʻikoʻi loa mai kahi molekala i kapa ʻia ʻo Nitric Oxide.
ʻO ka Lapaʻau Kukui ʻUlaʻula a me Rosacea
ʻO ke kumumanaʻo nui e wehewehe ana i nā hopena o ka hoʻōla kukui e hoʻokumu ʻia ana ma kahi molekala i kapa ʻia ʻo Nitric Oxide (NO).
He molekala kēia e hiki ke loaʻa nā hopena like ʻole i ke kino, e like me ke kāohi ʻana i ka hana ʻana o ka ikehu, ka vasodilation/hoʻonui ʻana o nā kīʻaha koko, a pēlā aku. ʻO ka mea a mākou e makemake nui ai no ka hoʻōla kukui, ʻo ia ka hoʻopaʻa ʻana o kēia NO ma kahi koʻikoʻi i loko o kāu kaulahao lawe electron mitochondrial, e hoʻōki ana i ke kahe o ka ikehu.
Hoʻopaʻa ia i nā pae hope loa o ka hopena hanu, no laila ke kāohi nei iā ʻoe i ka loaʻa ʻana o ka hapa nui o ka ikehu (ATP) a me kekahi kalapona ʻokikene mai ka glucose/oxygen. No laila, i ka wā e emi mau ai ka nui o ka metabolic o ka poʻe i ko lākou ʻelemakule ʻana a i ʻole ke kaumaha/pōloli, ʻo kēia NO ke kuleana. He mea kūpono ia i kou noʻonoʻo ʻana, ma ke ʻano a i ʻole ke ola ʻana, pono ʻoe i kahi ʻano hana e hoʻohaʻahaʻa i kāu metabolic rate i ka wā o ka loaʻa ʻana o ka meaʻai/calorie haʻahaʻa. ʻAʻole ia he mea kūpono i ka honua hou kahi e hiki ai ke hoʻopili ʻia nā pae NO e nā ʻano amino acids kikoʻī i ka meaʻai, ka haumia o ka ea, ka ʻōpala, nā meaʻai ʻē aʻe, ka mālamalama artificial, a pēlā aku. ʻO ka nele o ke kalapona ʻokikene i loko o ko mākou kino e hoʻonui pū i ka mumū.
Hoʻonui ka lāʻau kukui i ka hana ʻana o ka ikehu (ATP) a me ke kalapona ʻokikene (CO2). ʻO ka CO2 ma ka huli ʻana e kāohi i nā cytokines pro-inflammatory like ʻole a me nā prostaglandins. No laila, hoʻemi ka lāʻau kukui i ka nui o ka mumū i loko o ke kino/wahi.
No ka rosacea, ʻo ka mea nui e lawe ʻia, ʻo ia ka hoʻēmi ʻana o ka lāʻau lapaʻau kukui i ka mumū a me ka ʻulaʻula ma ia wahi, a e hoʻoponopono pū i ka pilikia o ka hoʻohana ʻana i ka oxygen haʻahaʻa (ka mea i hoʻoulu ai i ka ulu ʻana o nā kīʻaha koko a me ka ulu ʻana o ka fibroblast).
Hōʻuluʻulu manaʻo
Aia nā ʻano like ʻole a me nā hōʻike o ka rosacea
He hōʻailona ʻo Rosacea o ka ʻelemakule, e like me nā wrinkles a me ka lauoho hina
ʻO ke kumu kumu o ka rosacea ka hoʻemi ʻia ʻana o ka hana mitochondrial i loko o nā pūnaewele
Hoʻihoʻi ka lāʻau lapaʻau kukui ʻulaʻula i ka mitochondria a hoʻemi i ka mumū, e pale ana i ka rosacea