ʻO Rosacea kahi maʻi i hōʻike ʻia e ka ʻulaʻula o ka maka a me ka pehu.Pili ia ma kahi o 5% o ka heluna kanaka o ka honua, a ʻoiai ua ʻike ʻia nā kumu, ʻaʻole i ʻike nui ʻia.Manaʻo ʻia he maʻi ʻili lōʻihi, a pili pinepine i nā wahine ʻEulopa / Caucasian ma mua o 30 mau makahiki.
Hoʻomaʻamaʻa maikaʻi ʻia ka lāʻau ʻulaʻula no nā mea e like me ka ho'ōla ʻana i ka ʻili, ka mumū ma ke ʻano nui, ka collagen i loko o ka ʻili, a me nā ʻano ʻili like ʻole e like me ka haki.Ua ulu maoli ka hoihoi i ka hoʻohana ʻana i ke kukui ʻulaʻula no ka rosacea.Ma kēia ʻatikala e nānā mākou inā hiki ke kōkua i ka lāʻau kukui ʻulaʻula (ʻike ʻia ʻo photobiomodulation, LED therapy, laser therapy, cold laser, light therapy, LLLT, etc.) ke kōkua i ka mālama ʻana i ka rosacea.
ʻO nā ʻano Rosacea
ʻO kēlā me kēia mea i loaʻa i ka rosacea he mau hōʻailona ʻokoʻa a ʻokoʻa.ʻOiai pili pinepine ʻia ka rosacea me ka ʻulaʻula o ka maka a puni ka ihu a me nā papalina, aia kekahi mau hōʻailona ʻē aʻe i hiki ke wāwahi ʻia a hoʻokaʻawale ʻia i loko o nā 'subtypes' rosacea:
ʻO ka subtype 1, i kapa ʻia ʻo 'Erythematotelangiectatic Rosacea' (ETR), ʻo ia ka stereotypical rosacea e hōʻike ana me ka ʻulaʻula o ka maka, ka ʻili ʻili, nā kīʻaha koko kokoke i ka ʻili a me nā manawa o ka ʻili.Mai ka huaʻōlelo Helene erythros, ʻo ia hoʻi ka ʻulaʻula - a pili i ka ʻili ʻulaʻula.
ʻO Subtype 2, Acne rosacea (inoa ʻepekema - papulopustular), he rosacea kahi i hui pū ʻia ai ka ʻili ʻulaʻula me nā ʻano ʻeʻe like ʻole a i ʻole intermittent (pustules a me papules, ʻaʻole ʻeleʻele).Hiki i kēia ʻano ke hoʻoulu i ka ʻeha a i ʻole ka ʻeha.
ʻO ka subtype 3, AKA phymatous rosacea a i ʻole rhinophyma, he ʻano laha loa o ka rosacea a loaʻa nā ʻāpana o ka maka e mānoanoa a nui aʻe - ʻo ka maʻamau ka ihu (ihu ʻuala).He mea maʻamau ia i nā kāne kahiko a hoʻomaka ma ke ʻano he subtype o rosacea.
ʻO ka subtype 4 ka rosacea o ka maka, a i ʻole ka rosacea ocular, a pili ia i nā maka koko, nā maka wai, ka manaʻo o kekahi mea i ka maka, ʻā, ʻāʻī a me ka ʻāʻī.
He mea nui ka ʻike e pili ana i nā subtypes o ka rosacea i ka hoʻoholo inā loaʻa iā ʻoe.Inā ʻaʻohe hana e hoʻoponopono i ka rosacea, ʻoi aku ka maikaʻi o ka wā.ʻO ka mea pōmaikaʻi, ʻaʻole loli ka hoʻohana ʻana o ka ʻulaʻula ʻulaʻula i ka mālama ʻana i ka rosacea me ka subtype.ʻO ka manaʻo e hana ka protocol therapy ʻulaʻula like no nā ʻano ʻano āpau.No ke aha mai?E nānā kākou i nā kumu o ka rosacea.
ʻO ke kumu maoli o Rosacea
(… a no ke aha e hiki ai ke kōkua ka lāʻau māmā)
He mau makahiki i hala aku nei, ua manaʻo mua ʻia ka rosacea i ka hopena o kahi maʻi bacteria.I ka hana ʻana o nā lāʻau antibiotic (me ka tetracycline) i kahi pae e mālama i nā hōʻailona, me he manaʻo maikaʻi ia…
ʻO ka hapa nui o nā kauka a me nā loea e pili ana i ka rosacea i kēia mau lā e haʻi iā ʻoe he enigmatic ka rosacea a ʻaʻohe mea i ʻike i ke kumu.E kuhikuhi kekahi i nā mites Demodex ke kumu, akā aneane loaʻa kēia mau mea āpau a ʻaʻole nā mea āpau i rosacea.
A laila e hoʻopaʻa inoa lākou i nā 'hoʻomaka' like ʻole ma kahi o ke kumu, a i ʻole e manaʻo i nā genetics i ʻike ʻole ʻia a me nā kumu kaiapuni ke kumu.ʻOiai hiki i nā kumu genetic a i ʻole epigenetic ke manaʻo mua i ka loaʻa ʻana o ka rosacea (pili i kekahi kanaka), ʻaʻole lākou e hoʻoholo - ʻaʻole lākou ke kumu.
ʻO nā kumu like ʻole e hoʻopili maoli i ka paʻakikī o nā hōʻailona rosacea (caffeine, nā mea ʻala, kekahi mau meaʻai, ke anuanu / wela, ke kaumaha, ka waiʻona, a me nā mea ʻē aʻe), akā ʻaʻole lākou ke kumu kumu.
No laila he aha?
Nā hōʻailona i ke kumu
ʻO ka ʻike mua i ke kumu, ʻo ia ka ulu ʻana o ka rosacea ma hope o ka makahiki 30. ʻO ia ka makahiki i ʻike ʻia ai nā hōʻailona mua o ka ʻelemakule.E ʻike ka hapa nui o ka poʻe i ko lākou lauoho hina mua a me ka wrinkle ʻili liʻiliʻi mua a puni kēia makahiki.
ʻO kekahi ʻike ʻē aʻe ʻo ka ʻoiaʻiʻo e kōkua nā lāʻau antibiotic i ka mālama ʻana i nā hōʻailona - ʻoiai ʻaʻohe maʻi maoli (hint: hiki i nā lāʻau antibiotic ke loaʻa nā hopena anti-inflammatory wā pōkole).
ʻO ke kahe o ke koko i ka ʻili i hoʻopilikia ʻia e ka rosacea he 3 a 4 mau manawa kiʻekiʻe ma mua o ka ʻili maʻamau.Loaʻa kēia hopena hyperemia ke hiki ʻole i nā ʻiʻo a me nā cell ke lawe i ka oxygen mai ke koko.
Ua ʻike mākou ʻaʻole ʻo ka rosacea he pilikia hoʻonaninani wale nō, akā pili i nā loli ulu fibrotic koʻikoʻi i ka ʻili (no laila ka ihu ʻuala ma subtype 3) a me ka ulu ʻana o ka moku koko invasive (no laila veins/flushing).Ke loaʻa kēia mau hōʻailona like ma nā wahi ʻē aʻe o ke kino (e laʻa i ka fibroids uterine) pono lākou i ka noiʻi nui, akā i ka ʻili, hoʻokuʻu ʻia lākou i nā pilikia hoʻonaninani e 'mālama ʻia' e ka 'alo ʻana i nā mea hoʻoulu', a ma hope o nā ʻokiʻoki e wehe i ka ʻili mānoanoa. .
He pilikia koʻikoʻi ʻo Rosacea no ka mea ʻo ke kumu kumu he kaʻina hana physiological i loko o ke kino.ʻAʻole pili ka ʻili wale nō ke kūlana physiological e alakaʻi ana i kēia mau hoʻololi ʻili - pili pū kekahi i ke kino holoʻokoʻa.
Hiki ke ʻike koke ʻia ka ʻili, ka ulu ʻana/invasive a me ka mānoanoa o ka ʻili i ka rosacea, no ka mea, ʻike ʻia i ka ʻili - ka ʻili o ke kino.Ma ke ʻano, he pōmaikaʻi ka loaʻa ʻana o nā hōʻailona rosacea, no ka mea e hōʻike ana iā ʻoe he hewa kekahi mea i loko.He ʻano like ka pohō o ka lauoho ma ke ʻano o ke kāne ma ke kuhikuhi ʻana i ka dysregulation hormonal.
Nā hemahema mitochondrial
ʻO nāʻike a me nā ana a pau e pili ana i ka rosacea e kuhikuhi ana i nā pilikia mitochondrial ma ke kumu kumu o ka rosacea.
ʻAʻole hiki i ka Mitochondria ke hoʻohana pono i ka oxygen i ka wā e pōʻino ai lākou.ʻO ka hiki ʻole ke hoʻohana i ka oxygen e hoʻonui i ke kahe koko i kahi kiko.
Hoʻopuka ka Mitochondria i ka waikawa lactic ke hiki ʻole iā lākou ke loaʻa a hoʻohana i ka oxygen, e alakaʻi i ka vasodilation koke a me ka ulu ʻana o nā fibroblasts.Inā hoʻolōʻihi ʻia kēia pilikia i kekahi manawa, hoʻomaka nā kīʻaha koko hou e ulu.
Hiki i nā ʻano hormonal like ʻole a me ke kaiapuni ke kōkua i ka hana mitochondrial maikaʻi ʻole, akā i ka pōʻaiapili o ke kukui ʻulaʻula, ʻo ka hopena nui loa mai kahi mole i kapa ʻia ʻo Nitric Oxide.
ʻO ke kukui ʻulaʻula a me ka Rosacea
Hoʻokumu ʻia ke kumumanaʻo nui e wehewehe ana i ka hopena o ka lāʻau māmā ma kahi mole i kapa ʻia ʻo Nitric Oxide (NO).
He moleke kēia e hiki ke loaʻa i nā hopena like ʻole i ke kino, e like me ke kāohi ʻana i ka hana ikehu, vasodilation / hoʻonui i nā kīʻaha koko, a pēlā aku.ʻO ka mea a mākou e makemake nui ai no ka hoʻomaʻamaʻa māmā ʻo ia ka NO i hoʻopaʻa ʻia ma kahi wahi koʻikoʻi i kāu kaulahao transport electron mitochondrial, e hoʻōki i ka kahe o ka ikehu.
Hoʻopaʻa ʻo ia i nā pae hope loa o ka hoʻoulu ʻana o ka hanu, no laila ke kāpae nei ʻoe i ka loaʻa ʻana o ka puʻupuʻu nui o ka ikehu (ATP) a me nā kalapona kalapona mai ka glucose/oxygen.No laila, ke hoʻohaʻahaʻa mau ka poʻe i ka nui o ka metabolic i ko lākou mau makahiki a i ʻole nā manawa o ke kaumaha / pōloli, ʻo kēia NO ke kuleana.Maikaʻi ke noʻonoʻo ʻoe iā ia, ma ke ʻano a i ʻole ke ola ʻana, pono ʻoe i kahi mīkini e hoʻohaʻahaʻa i kāu helu metabolic i nā manawa o ka loaʻa ʻana o ka meaʻai/calorie haʻahaʻa.ʻAʻole i manaʻo nui ʻia i ka honua hou kahi hiki ke hoʻopili ʻia nā pae NO e nā ʻano amino acid i loko o ka meaʻai, ka haumia o ka ea, ka polū, nā kumu meaʻai ʻē aʻe, nā kukui artificial, etc. ʻO ka nele o ka carbon dioxide i loko o ko mākou kino. ramps up inflammation.
Hoʻonui ka hoʻomaʻamaʻa māmā i ka hana o ka ikehu (ATP) a me ka carbon dioxide (CO2).ʻO ka CO2 ka mea e pale ai i nā cytokines pro-inflammatory a me prostaglandins.No laila, hoʻemi ka lāʻau māmā i ka nui o ka mumū i loko o ke kino / wahi.
No ka rosacea, ʻo ka hoʻomaʻamaʻa māmā e hoʻemi i ka mumū a me ka ʻulaʻula o ka wahi, a hoʻonā i ka pilikia o ka hoʻohana haʻahaʻa oxygen (ʻo ia ka mea i ulu ai ka moku koko a me ka ulu fibroblast).
Hōʻuluʻulu manaʻo
Aia nā ʻano subtypes a me nā hōʻike o ka rosacea
ʻO Rosacea kahi hōʻailona o ka ʻelemakule, e like me nā wrinkles a me ka lauoho hina
ʻO ke kumu kumu o ka rosacea ua hoʻemi ʻia ka hana mitochondrial i nā cell
Hoʻihoʻi hou ka lāʻau ʻulaʻula i ka mitochondria a hoʻemi i ka mumū, pale i ka rosacea
Ka manawa hoʻouna: Sep-30-2022