ʻO ka maʻi o Alzheimer, kahi maʻi neurodegenerative holomua, e hōʻike ʻia ma o nā hōʻailona e like me ka nalowale o ka hoʻomanaʻo, aphasia, agnosia, a me ka hana hoʻokō impaired. ʻO ka mea maʻamau, ua hilinaʻi nā mea maʻi i nā lāʻau lapaʻau no ka hōʻoluʻolu o ka hōʻailona. Eia nō naʻe, ma muli o nā palena a me nā hopena ʻaoʻao o kēia mau lāʻau lapaʻau, ua huli ka poʻe noiʻi i ko lākou nānā ʻana i ka phototherapy non-invasive, e loaʻa ana i nā holomua nui i nā makahiki i hala.
I kēia mau lā, ua ʻike kahi hui i alakaʻi ʻia e Professor Zhou Feifan mai ke Kulanui ʻEnekinia Biomedical o Hainan University e hiki i ka phototherapy transcranial hoʻopili ʻole ke hoʻohaʻahaʻa i nā hōʻailona pathological a hoʻonui i ka noʻonoʻo noʻonoʻo i nā ʻiole ʻelemakule a me Alzheimer. ʻO kēia ʻike ʻike honua, i paʻi ʻia ma ka puke pai Nature Communications, hāʻawi i kahi hoʻolālā hoʻohiki no ka mālama ʻana i nā maʻi neurodegenerative.
Ka hoʻomaopopo ʻana i ka maʻi maʻi o Alzheimer
ʻAʻole maopopo ke kumu maoli o ka maʻi o Alzheimer, akā ua hōʻike ʻia e ka hōʻuluʻulu ʻana o ka protein beta-amyloid a me ka neurofibrillary tangles, e alakaʻi ana i ka neuronal dysfunction a me ka emi ʻana o ka cognitive. ʻO ka lolo, ʻo ia ka mea hana ʻoi loa o ke kino, e hana i ka ʻōpala metabolic nui i ka wā o ka hana neural. ʻO ka hōʻiliʻili nui ʻana o kēia ʻōpala hiki ke hōʻino i nā neurons, pono e hoʻoneʻe maikaʻi ʻia ma o ka ʻōnaehana lymphatic.
ʻO nā moku lymphatic meningeal, koʻikoʻi no ka hoʻoheheʻe ʻana o ka ʻōnaehana nūnū waena, ke kuleana nui i ka hoʻomaʻemaʻe ʻana i nā protein beta-amyloid ʻawaʻawa, ka ʻōpala metabolic, a me ka hoʻoponopono ʻana i ka hana kūlohelohe, e hoʻolilo iā lākou i pahuhopu no ka mālama ʻana.
ʻO ka hopena o Phototherapy i ka maʻi Alzheimer
Ua hoʻohana ka hui ʻo Polofesa Zhou i kahi laser kokoke-infrared 808 nm no ʻehā pule o ka non-contact transcranial phototherapy ma luna o nā ʻiole a me Alzheimer. ʻO kēia lapaʻau i hoʻonui nui i ka hana o ka maningeal lymphatic endothelial cell, hoʻomaikaʻi i ka wai lymphatic, a hoʻopau i nā hōʻailona pathological a hoʻomaikaʻi i nā hana cognitive i nā ʻiole.
Hoʻolaha i ka hana Neuronal ma o Phototherapy
Hiki i ka Phtotherapy ke hoʻonui a hoʻomaikaʻi i ka hana neuronal ma o nā ʻano hana like ʻole. No ka laʻana, he hana koʻikoʻi ke kaʻina hana immune i ka pathology o Alzheimer. Hōʻike nā haʻawina hou e hiki i ka 532 nm green laser irradiation ke hoʻoikaika i ka hana o ka cell immune, ka hoʻoulu ʻana i nā mīkini intrinsic i loko o nā neurons hohonu hohonu, ka hoʻomaikaʻi ʻana i ka dementia vascular, a me ka hoʻonui ʻana i ke kahe koko a me nā hōʻailona maʻi i nā maʻi o Alzheimer. Ua hōʻike ʻia ka hoʻomaʻamaʻa ʻana o ka laser vascular irradiation mua i ka viscosity koko, plasma viscosity, red blood cell aggregation, a me nā hoʻokolohua neuropsychological.
Hiki i ka ʻulaʻula a me ka infrared light therapy (photobiomodulation) i hoʻohana ʻia i nā wahi o ke kino peripheral (hope a me nā wāwae) hiki ke hoʻōla i nā cell immune a i ʻole nā mea hana pale i loko o nā cell stem, e hāʻawi ana i ke ola neuronal a me ka hōʻike gen pono.
ʻO ka pōʻino oxidative kekahi kaʻina pathological koʻikoʻi i ka hoʻomohala ʻana o Alzheimer. Hōʻike ka noiʻi e hiki i ka ʻulaʻula ʻulaʻula ke hoʻonui i ka hana ATP cellular, hoʻoulu i ka neʻe metabolic mai ka glycolysis i ka hana mitochondrial i ka microglia inflammatory i hoʻopilikia ʻia e ka oligomeric beta-amyloid, hoʻonui i nā pae microglia anti-inflammatory, hoʻemi i nā cytokine pro-inflammatory, a me ka hoʻoulu ʻana i ka phagocytosis e pale ai i ka neuronal. make.
ʻO ka hoʻomaikaʻi ʻana i ka makaʻala, ka ʻike, a me ka nānā mau ʻana kekahi ala kūpono e hoʻonui ai i ka maikaʻi o ke ola o nā maʻi o Alzheimer. Ua ʻike ka poʻe noiʻi he hopena maikaʻi ka ʻike ʻana i ke kukui uliuli lōʻihi pōkole i ka hana naʻau a me ka hoʻoponopono naʻau. Hiki i ka ʻulaʻula ʻulaʻula ke hoʻoikaika i ka hana kaapuni neural, hoʻoikaika i ka hana o ka acetylcholinesterase (AchE) a me ka choline acetyltransferase (ChAT), a laila e hoʻomaikaʻi ai i ke aʻo ʻana a me ka hoʻomanaʻo.
Nā hopena maikaʻi o Phototherapy ma luna o nā neuron lolo
Ke hōʻoia nei ka ulu ʻana o ka noiʻi mana i nā hopena maikaʻi o ka phototherapy i ka hana neuron lolo. Kōkua ia i ka hoʻoikaika ʻana i nā mīkini pale intrinsic o nā cell immune, hoʻoikaika i ka hōʻike ʻana o ke ola neuronal, a kaulike i nā pae ʻano oxygen reactive mitochondrial. Hoʻokumu kēia mau ʻike i kumu paʻa no nā noi lapaʻau o phototherapy.
Ma muli o kēia mau ʻike, ua hana ka MERICAN Optical Energy Research Center, me ka hui pū ʻana me kahi hui Kelemania a me nā kulanui he nui, noiʻi, a me nā keʻena olakino, i hana i kahi noiʻi e pili ana i nā poʻe o 30-70 me ka haʻahaʻa cognitive impairment, ka emi ʻana o ka hoʻomanaʻo, ka emi ʻana o ka ʻike a me ka hoʻoholo. a me ka emi ʻana o ka hiki ke aʻo. Hoʻopili ka poʻe i komo i nā alakaʻi o ka ʻai a me ke ola olakino i ka wā e hana ana i ka phototherapy i loko o ke keʻena olakino MERICAN, me nā ʻano lāʻau lapaʻau a me nā ʻano.
Ma hope o ʻekolu mahina o nā hoʻokolohua neuropsychological, nā hoʻokolohua noʻonoʻo noʻonoʻo, a me nā loiloi cognitive, ua hōʻike nā hopena i ka hoʻomaikaʻi nui ʻana i nā helu MMSE, ADL, a me HDS ma waena o nā mea hoʻohana phototherapy hale olakino. Ua ʻike pū ka poʻe i komo i ka hoʻonui ʻana i ka nānā maka, ka maikaʻi o ka hiamoe, a me ka hoʻemi ʻana i ka hopohopo.
Hōʻike kēia mau ʻike e hiki i ka phototherapy ke lawelawe ma ke ʻano he lāʻau kākoʻo e hoʻoponopono i ka hana o ka lolo, hoʻēmi i ka neuroinflammation a me nā pathologies pili, hoʻomaikaʻi i ka cognition, a hoʻonui i ka hoʻomanaʻo. Eia kekahi, wehe ia i nā ala hou no ka phototherapy e hoʻololi i kahi ala therapeutic preventive.
